Abstract

NANOPARTICLES: AN APPROACH FOR NOVEL DRUG DELIVERY SYSTEM-A REVIEW

Dr. Tushar N. Lokhande and Suraj A. Raut*

Abstract

Nanotechnology defined as a tiny science. Nanotechnology is refered as design characterization, production, and applications of structures, devices and systems by controlling shape and size at nanometer scale. which we can achieve better therapeutic action, better bioavailability and better patient compliance by Nanotechnology. Nano-formulations are successfully used for brain delivery which includes nanoparticles system (polymeric/solid lipid), liposomes, dendrimers, nanoemulsions, nanosuspension and ligand mediated nanosystems. Nanoparticles are defined as particulate dispersions or solid particles drug carrier that may not be biodegradable. Several techniques are used for preparation of nanoparticles like Solvent Evaporation, Double Emulsification method, Emulsions - Diffusion Method, Nanoprecipitation, Coacervation method, and Supercritical fluid technology. Nanoparticles are subjected to several evaluation parameters such as yield of nanoparticles, Drug Content / Surface entrapment/Drug entrapment, Particle Size, SEM, TEM, Zeta Potential, Surface Morphology, In-vitro release Study, Kinetic Study and Stability.

Keywords: Advantages of nanoparticle, classification of nanoparticle, preparation technique, evaluation of nanoparticle, application.