Abstract

DESIGN AND DEVELOPMENT OF BOSWELLIC ACID LOADED NANOSTRUCTURED LIPID CARRIER BASED ANTI PSORIATIC NANO GEL FOR DERMAL DELIVERY

Sharda Shinde*, Kabirdas Ghorpade and Dr. S. G. Gattani

Abstract

Anti-inflammatory activity Boswellia serrata is mainly due to 11-keto- β-boswellic acid (KBA) which has the activity against the production of leukotrienes by inhibition of 5- lipooxygenase. However, most recent research shows that Boswellic acid could also play an important role in targeting the microsomal prostaglandin synthesis inhibition, which is the major inflammatory mediator. Boswellic acid acts by inhibiting excessive activation of nucleic acid transcription factors TNF-kappa-β in diseased skin and preventing TNF alpha from being excessively synthesized, this mechanistic account of Boswellic acid helps in curing psoriasis.

Keywords: Anti-inflammatory activity, Boswellia Serrate, lipooxygenase.