Abstract

UV-VISIBLE SPECTROPHOTOMETRIC ESTIMATIONOFAMLODIPINE BESYLATE AND TELMISARTAN BY AUC METHOD IN BULK DRUG AND TABLET DOSAGE FORM

M. T. Mohite*, R. A. Bhalchakra and K. V. Chandgude

Abstract

A simple, rapid, reproducible and accurate UV spectrophotometric method has been developed for the estimation of Amlodipine besylate (AML) and Telmisartan (TEL) in bulk drug form by Simultaneous and AUC method. Evaluation of tablet is determined by the multi wavelength and AUC technique, at the wavelength of 360nm and 298nm over the concentration of 5–30 μg/ml and 1–15 μg/ml with mean recovery more than 98% and area of Amlodipine besylate and Telmisartan at absorption maxima, which is 360±10 and 298±10. The results of the analysis were validated as per the ICH guidelines. Thus the developed method can be successfully used for Simultaneous and AUC determination of Amlodipine besylate and Telmisartan.

Keywords: Amlodipine besylate, Telmisartan, Spectrophotometric, Simultaneous, AUC.