Abstract

L-THEANINE SHOWING THE NEUROPROTECTIVE ACTIVITY AGAINST LIPOPOLYSACCHARIDE INDUCED NEUROINFLAMMATION IN MICE MODEL

Mohan Lal, Pawankumar Rai, Saumiya Gupta, Manik Bainwad*

Abstract

Neuroinflammation is associated with a number of neurodegenerative diseases such as Alzheimer’s disease. It is reported that lipopolysaccharide (LPS) can induce neuroinflammation and cognitive impairment. L-Theanine is non-protein amino acid obtained from tea leaves Camellia sinensis and it is identified to possess neuroprotective activity. The aim of this study was to explore the possibility of LTheanine in preventing LPS induced cognitive impairment. The study was carried out on Swiss albino mice in different groups by giving saline, L-Theanine (2mg/kg, 4mg/kg), LPS (0.25mg/kg) and Rivastigmine respectively. Various behavioral parameters and antioxidant assays were carried out. L-Theanine demonstrated antioxidant activity and significant increase in memory as evidenced by Y-maze spontaneous alteration test and Morris water maze test.

Keywords: Alzheimer’s disease, Cognitive impairment, Neuroprotective, Lipopolysaccharide, L- Theanine, Antioxidant.