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Abstract

CLINICAL ASSESSMENT OF COGNITIVE IMPAIRMENT IN VARIOUS CONDITIONS OF HYPOTHYROIDISM PATIENTS

S. Anandkumar* and S. Venkatesh

Abstract

Aim/objective: To assess the cognitive impairment in variousconditions of hypothyroidism patients. To investigate MMSE score inhypothyroid and euthyroid subjects to explore the relationship betweenthyroid dysfunction and cognition. To assess the MMSE score on themood and cognitive changes associated with subclinicalhypothyroidism (SCH). To assess the MMSE score on the mood andcognitive changes associated with overt hypothyroidism. To explorethe association between education status of the patients with MMSEscores. Methods: It was a cross sectional observational case controlstudy. Result: The average MMSE score of hypothyroid patients was22.56±3.36, average MMSE score of control group is 24.94±2.48 (**p<0.0001). The average MMSE score of subclinical hypothyroidismpatients was 21.93±2.93, average MMSE score of control group is 24.94±2.48 (*p<0.001).The average MMSE score of overt hypothyroidism patients was 23.32±3.72, average MMSEscore of control group is 24.94±2.48 (*P<0.0031). Conclusion: Present study indicatinghypothyroidism patients have low MMSE score than euthyroid participants which revealshypothyroidism is significantly associated with cognitive impairment. Our finding revealsthat SCH was significantly associated with mild cognitive impairment more research isrequired to determine the nature and extent of this association. Present study also reveals theassociation between overt hypothyroidism and mild cognitive impairment. Our finding showsthat SCH have higher risk of cognitive impairment than overt hypothyroidism in this sample.Present study also reveals patients who have chronic thyroid damage leads to higher risk ofcognitive impairment.

Keywords: SCH, overt hypothyroidism, MMSE, cognitive impairment.


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