Abstract

EFFICACY OF INDOMETHACIN COMPARED WITH MAGNESIUM SULFATE IN THE MANAGEMENT OF PRETERM LABOR IN PREGNANCIES LESS THAN 32 WEEKS

*Rafah Mousa Khalaf and Maysoon Kareem Obaid

Abstract

The discovery of the ferroportin-hepcidin complex has led to a critical review on the treatment of anemia and anemia of inflammation (AI). Ferroportin, the only known mammalian iron exporter from cells to blood, is negatively regulated by hepcidin, a hormone peptide able to bind to ferroportin, leading to its degradation. Therefore, new efficient therapeutic interventions acting on hepcidin and ferroportin are imperative to manage anemia and AI. Bovine milk derivative lactoferrin (bLf), a glycoprotein able to chelate two ferric ions per molecule, is emerging as a natural anti-inflammatory substance able to modulate hepcidin and ferroportin synthesis through the down-regulation of interleukin-6 (IL-6). Here, an interventional study whıch done on Baghdad hospıtal was conducted by orally administering 100 mg of 20–30% iron-saturated bit (corresponding to 70–84 μg of elemental iron) twice a day. This treatment was compared with the other standard therapy, consisting in the oral administration of 329.7 mg of ferrous sulfate once a day (corresponding to 105 mg of elemental iron).

Keywords: Lactoferrin, iron, anemia, anemia of inflammation, ?-thalassemia, hereditary thrombophilia - eff?cacy - ?ndomethac?n - magnes?um sulfate - preterm labor – pregnanc?es.