Abstract

EFFICACY EVALUTION OF STANDARDIZED FENUGREEK SEEDS EXTRACT AS FUROSTANOLIC SAPONINS & MYO-INOSITAL (NUTRICYST-M) IN MANAGEMENT OF INSULIN RESISTANCE (IR) & OVARY VOLUME IN PCOS SUBJECTS

Amrita Sarkari Jaipuriar*, Arshia Malik and Gopesh Lamgora

Abstract

Objective: Polycystic ovarian syndrome is affecting nearly 6-10% of women of reproductive age. A frequent feature of women with PCOS is insulin resistance accompanied by compensatory hyperinsulinemia, and increasing evidence suggests that hyperinsulinemia plays an important role in the pathogenesis of PCOS, pointing the way to new and novel therapy for PCOS. The study was planned with one natural alternative remedy Standardized Fenugreek seeds extract as Furostanolic saponins and Myo-inositol. Standardized Fenugreek seeds extract as Furostanolic saponins which contains bioactive components Saponins extracted from Fenugreek seeds improves insulin sensitivity and, in turn, may regulate circulating androgen levels. It improves insulin-mediated glucose disposal in women with PCOS. It also decrease in LH/FSH ratio observed in my last study. Myo-inositol improves fertility by lowering male sex hormones in both women with and without PCOS. But it could also improve ovulation in women with PCOS. Myo-inositol also reduces insulin resistance and increases estrogen levels. Myo-inositol reduced testosterone, luteinizing hormone (LH), and insulin levels. Present observation study is to establish efficacy and safety in management of IR and ovarian volume. Methodology: Our specific objective was to establish the correlation of reduction in ovary volume and insulin resistance in obese women with PCOS, treated with Standardized Fenugreek seeds extract as Furostanolic Saponins and Myo-inosital (Nutricyst- M). Material & Method:- An open labeled, single armed and non comparative observation study conducted in 30 female patients suffering from PCOS with high insulin resistance and acanthosis nigricans. The subjects were screened for the enrolment on the basis of following inclusion & exclusion criteria:

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