Abstract

DESIGN AND OPTIMIZATION OF MICROEMULSION FORMULATION FOR TOPICAL DELIVERY OF LORNOXICAM

Nandkishor Sudam Wani* Amol Pandurang Ilag and Niraj Nemichand Sanghai

Abstract

The purpose of the present study was to assess and optimize the promising use of microemulsions as a topical drug delivery for poorly water soluble NSAID, lornoxicam. The pseudo-ternary phase diagrams were developed for various microemulsion formulations composed of Oleic acid (oil phase), Tween 80 (surfactant) and Propylene Glycol (co-surfactant) by using water titration method. Formulations of microemulsion with different proportions of oil, Surfactant (SAA), Cosurfactant (Co-SAA) was prepared and optimized using simplex lattice mixture design. The effect of independent variables (concentrations of surfactant: co-surfactant and water) were investigated on the particle size and cumulative amount of drug (lornoxicam) diffused per unit area (CADD) of excised mouse skin. The microemulsion was also evaluated for physicochemical properties like pH, viscosity, zeta potential and stability studies. The results showed that the optimized microemusion formulation was composed of oleic acid (5%, w/w), tween 80 (20% w/w), propylene glycol (30% w/w) and water (45% w/w). The mean particle diameter was 57.09 nm and the drug release was 29.53 %. Thus it was concluded that the permeating ability of lornoxicam was significantly increased from the microemulsion formulation.

Keywords: Topical delivery, Lornoxicam, Microemulsion, Simplex lattice mixture design.