Abstract

PURIFICATION CHARACTERIZATION AND ANALYTICAL EVALUATION OF SUSPENDING PROPERTIES OF AZADIRACHTA INDICIA AND ACACIA NILOTICA GUM

Punet Kumar, Rishi Kumar*, Vidhan Chand Bala, Sangam and Harjeet Singh

Abstract

Aim: The present research work was aimed at purification characterization and analytical evaluation of the suspending properties of Azadirachta indicia and Acacia nilotica gum. Methods: The present study aims to extract the gum from Acacia nilotica and Azadirachta indicia and then characterized to be used as an excipient. This study also aimed to search the cheap and effective excipients and evaluate the suspending properties of the different natural polymer (Acacia nilotica gum, Azadirachta indicia) on paracetamol suspension and compared with each other Acacia nilotica gum and Azadirachta indicia at the deliberation of 1-4%w/v be used to practice the suspension in which paracetamol is used as a model drug. Prepared suspensions were evaluated for sedimentation volume, flow rate, viscosity, and redispersibility number. The values performed are used as the basis for evaluating the suspended agents studied. Results: The results of the physiochemical investigation confirm that polysaccharides were absent in both polymers. Results obtained from the micromeritic characterization and flow behaviour showed that Acacia nilotica gum is a good candidate as compared to Azadirachta indicia to be used as a pharmaceutical excipient. Particles suspended with Azadirachta indicia gum at concentration 4%w/v re-dispersed easily than those formulated with the Acacia nilotica gum. Conclusions: Evaluation of suspending properties of both the gums suggests that Neem gum has good suspending properties than that of Babool gum. Therefore it is confirmed that both the gums possess good properties to use them as a pharmaceutical excipient.

Keywords: Polymer, suspending, sedimentation, Excipient, Acacia nilotica, Azadirachta indicia.