Abstract

AMELIORATING EFFECT OF CURCUMA LONGA ON STREPTOZOTOCIN INDUCED NEPHROTOXICITY IN SWISS ALBINO MICE

Pramod Shankar, Arun Kumar*, Ranjit Kumar*, Mohammad Ali* and Sudhir Kumar Srivastava

Abstract

Diabetes mellitus is a universal problem affecting human societies at all stages of development. It is a condition where sufficient amount of insulin is either not produced or the body is unable to use the insulin that is produced, leading to excess glucose in the blood. Various medicines have been discovered till date to control it but ethno drugs in the present day is in high demand as its side effects are very least. The aim of this study is to investigate the anti- diabetic and antitoxic effects of Curcuma longa (Turmeric) rhizome extract on Streptozotocin induced diabetic mice. The study was approved though the Institutional Animal Ethics Committee of the institute. Mice were grouped into 3 groups – Control (n=6), Streptozotocin treated (n=12) and Momordica charantia administered group (n=6). Treated group mice were administered with Streptozotocin 100 mg/kg body weight intraperitoneally. After the development of diabetes in mice the aqueous rhizome extract of Curcuma longa at the rate of 200 mg/kg body weight was administered for 4 weeks to evaluate its antihyperglycemic activity. There serum glucose levels as well as the Kidney Function Tests (KFT) – Urea, Uric Acid and Creatinine levels were analyzed statistically using ANOVA and Dunnett’s tests. The serum glucose levels shows increase in the levels in the Streptozotocin induced diabetic group in comparison to control group while the turmeric group showed the glucose lowering down activity denotes the antidiabetic effect. The Kidney function test showed significant elevation in the Urea, Uric Acid and Creatinine levels levels in Streptozotocin induced groups while the Turmeric showed significant decrease in in the KFT levels denotes the antitoxic effects. Thus, from the entire study it can be concluded that Turmeric can be used as potent natural anti-diabetic drug which can control the diabetes at much level furthermore it also prevents the Kidney from the diabetic damage and restores of cellular status of the kidney.

Keywords: Amelioration, Curcuma longa, Streptozotocin, Kidney Function Test.