FORMULATION AND EVALUATION OF FLOATING TABLET OF CAPTOPRIL
Sameer Singh1, A K Pathak1, Neelima Goswami2*
Abstract
Present investigation highlights the effectiveness of floating tablets of
Captopril formulated using different grades of
hydropropylrmethylecellulose. Lactose and citric acid were utilized in
different concentration as a channeling and chelating agent to obtain
best optimized formulation. Formulations were optimized on the basis
of floating lag time and in vitro drug release. Study revealed that
channeling and chelating agent had significant effect on the release of
the drug from floating hydrophilic matrix tablet. Three different
viscosity grades of hydropropylrmethylcellulose namely K100M, K
15M and K 4M were used as a floating polymer or intention of
polymer. It was observed that different viscosities not only influenced
the drug release from hydrophilic matrix but they also affected the
floating properties of the tablets. Dissolution profiles were subjected to various kinetic
treatments to analyze the release pattern of the drug and it was found that drug released from diffusion mechanism and followed Higuchi’s kinetics. The in vitro drug release profiles of
drug from all the plots showed high linearity (r2= 0.9813 to 0.9954). Optimized formulations
were again subjected for thickness, friability, hardness, uniformity of content, uniformity of
weight, in vitro dissolution. floating lag time, floating time and stability studies. Based on the
results it can be concluded that the floating formulation of Captopril can be deployed to
achieve better therapeutic effect through site specific delivery for effective period of time.
Moreover it may also be utilized to increase the bioavailability of the drug which in turn can
reduce the dose size.
Keywords: floating tablet, HPMC, MCC, Lactose, captopril.
[Full Text Article]