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Abstract

RP HPLC METHOD DEVELOPMENT AND ITS VALIDATION FOR SIMULTANEOUS DETERMINATION OF TELMISARTAN AND FINOFIBRATE

P. Pooja*, Dr. P. Arun, P. Shailendra, D. Neelesh Kumar and P. Bhavesh

Abstract

A reversed phase liquid chromatographic method with UV detection 290 nm for Telmisartan and Finofibrate assay in human plasma was developed and validated. chromatographic separations was achieved on Phenomenex(c-18 250 mm x 4.60 mm) column kept at 4-35tem with mobile phase (methenoal:water) at a flow rate of 1ml /mint the method was validated for its specificity, linearity, accuracy, LOD, LOQ and robustness based on ICH guidelines. The validation studies revealed satisfactory reasarch proposed method has been applied for the quantification of telmisartan and Finofibratein commercial samples.

Keywords: RP-HPLC, Telmisartan and Finofibrate, retention time, validations-linearity, accuracy, precision.


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