Abstract

DESIGN AND DEVELOPMENT OF LIPOSOME BY MICROENCAPSULATION VESICLE METHOD AND VAGINAL DELIVERY SYSTEM FOR VORICONAZOLE GEL

P. Ravindra*, Dr. P. Arun, P. Shailendra, P. Bhavesh and D. Neelesh

Abstract

The present investigation constitutes the design and development of liposome by microencapsulation vesicle method and vaginal delivery system for voriconazole and its in-vitro diffusion & ex-vivo membrane permeation study. Amount of polymer and the number of sonication cycle was varied in different batches of formulations. Size, size distribution, surface charge, entrapment efficiency and drug content were studied for each formulation batch. Optimization of formulation and process parameter resulted in the production of Voriconazole loaded liposomal suspension with particle size distribution ranging between 130 to 240 nm and entrapment efficiency around 55%. Invitro diffusion characterization using dialysis membrane was carried out to evaluate the release characteristics of the drug from optimized liposomal gel formulations with respect to the pure drug in gel. An increase in the cumulative release of the drug (1.160 mg) is observed in comparison to the pure drug (0.743 mg) at specified time. In case of ex-vivo permeation study on vaginal membrane of the goat, supported the in vitro results.

Keywords: Liposome, microencapsulation, voriconazole, in-vitro diffusion, polymer.