FORMULATION DEVELOPMENT AND EVALUATION OF TRANSDERMAL PATCHS OF ANTIEPILEPTIC DRUG
Dhananjay Kumar*, Sailesh Narayan and Shailendra Bindaiya
Abstract
The objective of present study is to determine the permeation of
Lamotrigine from transdermal patch into microcirculation of skin.
Matrix type transdermal drug delivery system (TDDS) of Lamotrigine
was prepared by the solvent evaporation technique. Several batches
were prepared by using combination of HPMC (400, 425 and 450mg)
and ethyl cellulose, Eudragit RSPO (50, 75 and 100 mg) in different
ratios. Propylene glycol was used as plasticizer and as a permeation
enhancer. Formulated transdermal patches were characterized for their
physicochemical parameters like thickness, tensile strength, folding
endurance, moisture content, moisture uptake and drug content uniformity. Patches were
evaluated for their in-vitro drug release profile and ex-vivo skin permeation studies. Patches
were also subjected to stability studies and skin irritation studies to determine their
compatibility with skin. Result of evaluation studies revealed that Lamotrigine can be
administered as a controlled drug delivery system to reduce frequency of drug administration.
But this hypothesis requires further confirmation via in-vivo pharmacodynamic and
pharmacokinetic studies in animal and human models.
Keywords: Lamotrigine, Transdermal, HPMC, EC, Eudragit, Eudragit, etc.
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