Abstract

POLYAMINES FROM REACTION OF ORGANOTIN DIHALIDES AND 3-AMINO-1,2,4-TRIAZOLE (3-AT)- SYNTHESIS AND ABILITY TO INHIBIT HUMAN CANCER CELL LINES

Charles E. Carraher, Jr.*, Michael R. Roner, Ryan Crichton, Jessica Frank, Alisa Moric-Johnson, Lindsey C. Miller, Francesca Mosca and Paul Slawek

Abstract

The formation of polyamines from reaction of 3-amino-1,2,4-triazole, 3-AT, with organotin dichlorides occurs rapidly employing the interfacial polycondensation reaction giving moderate yield and chain lengths. MALDI MS produces ion fragments to seven and nineteen units with good isotopic abundance matches. IR shows the absence of the internal ring NH consistent with the formation of Sn-N bands and inclusion of bands from both the organotin and 3-AT units. NMR results are also consistent with the proposed repeat unit. The polymers show good inhibition of a group of solid human cancer cell lines including breast, lung, prostrate, and pancreatic cancer and glioblastomas brain cancer cell lines. Thus, these polymers offer a wide range of ability to inhibit cancer cell lines.

Keywords: 3-amino-1,2,4-triazole, 3-AT, organotin, brain cancer, breast cancer, pancreatic cancer, polyamines, interfacial polymerization, glioblastomas brain cancer.