Abstract

EVALUATION OF SUB ACUTE TOXICITY STUDY ON SUYAMAKKINI CHENDHURAM

V. Vetriselvi and M. Thiruthani

Abstract

Plant medicine is the oldest form of health care known to mankind. In many countries, herbal medicines and related products are introduced into the market without safety or toxicological evaluation. The objective of this ‘Sub-Acute Toxicity Study of Suyamakkini Chendhuramon Wister Rats’ was to assess the toxicological profile of the test item when treated as a single dose. Animals should be observed for 28 days after the drug administration. This study provides information on the possible health hazards likely to arise from exposure over a relatively limited period of time. In conclusion, Suyamakkini Chenduram extract can be considered safe, as it did not cause either any lethality or adverse changes with general behavior of rats and also there were no observable detrimental effects (100, 150, to 200 mg/kg body weight) over a period of 28 days. Our results have demonstrated that the Suyamakkini Chenduramextractis relatively safe when administered orally in rats.

Keywords: Sub-Acute Toxicity, Suyamakkini Chendhuramon, Hematology, Clinical biochemistry, Histopahology.