Abstract

PRO-ANGIOGENIC PROPERTY IN SELECTED CEPHALOPOD EXTRACTS

Veena Desai and Gayathri N.*

Abstract

Marine chemicals often possess unique structures which confer significant biological activity and novel pharmacology. Molluscs are one of the phyla of invertebrate organisms which are known for their biological activities. This study was carried out to compare the proangiogenic activities of the cephalopods - Cistopus indicus, Loligo duvauceli, Sepia aculeata and Sepiella inermis. The digestive system of these organisms, including the digestive glands was isolated and processed for extraction in four different solvents viz, methanol, chloroform: methanol, n-hexane and distilled water. Estimation of protein, carbohydrates and lipids were carried out. Comparison of the activity of extracts on the angiogenesis was done using CAM assay. The highest proangiogenic activity was noted in the chloroform: methanol extract of the digestive system of Loligo duvauceli. Anti-angiogenic activity was noted in the aqueous extract of the same organism. The authors thank Department of Biotechnology, Government of India for the financial grants provided to carry out this work.

Keywords: Bioactivity, Chick chorioallantoic membrane, Octopus, Squid.