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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

EFFECT ON CANCER CELL GROWTH BY METHANOLIC EXTRACT OF GORDONIA OBTUSA WALL.EXUT AND ARN, AN ENDEMIC WILD TEA PLANT

Shalimol. A*, K. Arumugasamy, M. R. Udhayasankar, R. Nantha kumar, V. Asha devi and P. Uma Maheswari

Abstract

The methanolic extract of Gordonia obtusa (Theaceae) was evaluated for its effects on growth in two malignant cell lines including a Human Lung cancer cell lines (A549) and Colon cancer cell lines (HT-29) using MTT assay. In these cell lines studied, the extract decreased cell viability, inhibited cell proliferation, and induced cell death in a dose dependent manner. The ethanolic extract of G. obtusa showed good cytotoxicity and their IC50 values were found to be 35.12μg/mL and 6.65 μg/mL respectively. It could be a reliable source of potent pharmacophore for treatment of disease like cancer.

Keywords: Gordonia obtusa, Colon cancer, Lung cancer.

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