Abstract

ANXIOLYTIC AND ANTIEPILEPTIC EFFECTS OF ASAFOETIDA OLEO-GUM RESIN

Prashant P. Saxena*, Kalyani Divakar, Divakar Goli, Amlan Mishra

Abstract

Swiss albino mice were grouped and treated with either distilled water or diazepam (3 mg/kg p.o.) as standard or Asafoetida (286 or 667 mg/kg p.o.) 1 h before to evaluate anxiolytic activity by using Elevated Plus Maze (EPM) test, Light & dark test, Locomotor activity test and Rota rod test whereas Maximal electroshock (MES- 42 mA, 0.2 s) induced convulsion test and pentylenetetrazole (PTZ- 80 mg/kg i.p.) induced convulsion test were used for the assessment of the antiepileptic activity where phenytoin (25 mg/kg p.o.) or diazepam (5 mg/kg p.o.) was administered as reference standard respectively. Both the doses of Asafoetida did not show statistically significant anxiolytic effect in EPM Test and Light & Dark Test but showed significant (P

Keywords: Anxiolytic, Elevated plus maze, Light and dark, PTZ, GABA.