Abstract

EFFECT OF AGARICUS SUBRUFESCENS AS IMMUNOSTIMULANT/ IMMUNOMODULATORY USING IN VIVO AND INVITRO PROCEDURES EXPERIMENTAL ANIMALS

*N. Praveen, M. Jalaiah and D. Dhachinamoorthi

Abstract

Agaricus subrufescens possesses immunomodulatory activity. The aqueous and ethanolic extracts was administered at either (400mg/kg, p.o) and (200mg/kg, p.o). The evaluation of immunoprophylactic effect was also carried out to determined the effect of Agaricus subrufescens on specific immunity by challenge with 0.5ml/100gm dose of Escherichia coli was administered to determine the survival of the animals against invading pathogens. However, the aqueous and ethanolic extracts of Agaricus subrufescens reduced the mortality and decreased the abdominal peritonitis in immunoprophylactic effect. Based on the above observations, it was concluded that Aqueous extract and Ethanolic extracts of (Agaricus subrufescens) produced significant immunostimulatory effect in comparison with control and standard. This concludes that the Agaricus subrufescens has immunostimulatory effect.

Keywords: Agaricus subrufescens, immunostimulatory, Ethanolic extract.