Abstract

HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITIES 0F PIPER CHABA IN ALLOXAN INDUCED DIABETIC MICE

Md. Monirul Islam*, Md. Wasim Bari, Dil Afroza, Mst. Zenika Nasrin, Hasna Hena Laboni, Md. Abdul Jabbar, Sinthia and Mohammad Amirul Islam*

Abstract

Diabetes mellitus (DM) is a systemic metabolic disorders with several major health complications affecting both the quality and the length of life. The purpose of this study is to appraise the antidiabetic and antihyperlipidemic activities of the Piper chaba plant extract. Diabetes was induced in overnight fasted mice by a single intraperitoneal injection of Alloxan (80 mg/kg body weight) in a 0.1 M sodium citrate buffer (pH 4.5). The animals were divided into five groups with five animals in each and treated with both the acetone and ethanol extract of P. chaba at dose 100 mg/kg and 200 mg/kg body weight respectively. The results showed that P. chaba plant extract decrease blood glucose level significantly (p

Keywords: Diabetes, antidiabetic, P. chaba, lipid profile.