Abstract

ESTIMATION OF LOSARTAN POTASSIUM IN PHARMACEUTICAL FORMULATIONS: APPLICATION TO CONTENT UNIFORMITY TESTING

Nief Rahman Ahmed*, Mohammad Jassim Essa and Muna Sobhi Abdullah

Abstract

A simple, accurate, precise, rapid, economical and sensitive Uv spectrophotometric method has been developed for the estimation of losartan potassium in pharmaceutical preparations and environmental wastewater samples, which shows maximum absorbance at 230 nm in distilled water. Beer's law was obeyed in the range of 2-16 μg/ ml,with molar absorptivity of 2.706x104 L.mol-1.cm-1, relative standard deviation of the method was less than 1.7%, and accuracy (average recovery %) was 100 ± 1.0. No interference was observed from common excipients and additives often accompany with losartan potassium in pharmaceutical preparations. The method was successfully applied to the estimation of losartan potassium in pharmaceutical formulations (tablets) and content uniformity testing. The proposed method was validated by sensitivity and precision which proves suitability for the routine analysis of losartan potassium in true samples.

Keywords: losartan potassium, Estimation, Pharmaceutical Preparations, Content uniformity.