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Abstract

PROTECTIVE EFFECTS OF CACTUS AND/OR PAPAYA JUICES AGAINST HEPATIC AND TESTICULAR TOXICITY INDUCED BY CHLORPYRIFOS IN ALBINO RATS

Dr. Huda E. Mogahed*, Amira Abd El-Rhman, Nora M. El-Sheikh and Heba Barakat

Abstract

This study aimed to evaluate the effect of cactus and/or papaya juiceson chlorpyrifos induced toxicity in ratʼs liver and testes. A total ofsixty albino rats weighing (180g -200g) were used for this study. Ratswere divided into 5 groups each of 12 rats. First group was left ascontrol group. Second group was given chlorpyrifos 6mg/kg b wt. Theother three groups were given cactus, papaya juices and both of themas 20ml/kg b wt, subsequently along with chlorpyrifos dose. All doseswere orally administered daily for 28 successive days. At the end ofthe experimental period, blood samples, liver and testes were collectedfrom each rat for biochemical analysis. Oral administration ofchlorpyrifos for 28 days in a dose of 6 mg/kg bwt, significantlyincreased the percentage of DNA fragmentation, caspase-3 level in liver and testes tissues. Asignificant increase in serum alanine aminotransferase, aspartate aminotransferase, catalase,cytochrome P450, paraxonase-1 activity as well as tumor necrosis factor- α, malondialdehydeand follicle stimulating hormones levels and decrease in testosterone and luteinizing hormonelevels was observed. On the other hand the administration of tested chlorpyrifos with juices,reduce the percentage of DNA fragmentation, caspase-3 level and directed enzymes activityand hormones levels toward normal. The effect on the liver is one of the main toxic effects ofthis product. In conclusion cactus and papaya juices have beneficial effects as it tends todampen chlorpyrifos toxicity in rats.

Keywords: cactus, papaya, chlorpyrifos, testosterone, DNA fragmentation, paraxonase- 1.


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