Abstract

A REVIEW ON APPLICATION OF METABOLOMICS, LIQUID BIOPSY AND FOUNDATION ONE CDx IN CANCER

Chaithra Vemparala*, Sreenu Thalla and Padmalatha Kantamneni

Abstract

Cancer is a devastating disease that alters the metabolism of cells in the body. The metabolites can be detected using different techniques in which the novel one is metabolomics. These focus on metabolite profiling intra-cellularly or from circulating fluids of the body. Unlike the genomics and proteomics, the metabolomics is novel diagnostic tools that led to the development of precision medicine. On the other hand, to deliver precision medicine, the novel non-invasive techniques emerged in the field of oncology like liquid biopsies. The body fluids like saliva, urine, blood and stools can be utilized as diagnostic techniques for early detection of stages of cancer. The genetic mutations are most common in cancerous condition. To overcome this, foundation medicine has developed foundation one CDx (companion diagnostic) tool which is approved by Food and Drug Administration (FDA) that can detect 5 types of genetic alterations, deletions, insertions, substitutions (melanoma, non-small cell lung cancer, breast, ovarian and colorectal cancers) in a tumor cell. In this review, the emerging applications of metabolomics, various types of liquid biopsies and foundation one CDx are discussed.

Keywords: Cancer, metabolomics, liquid biopsy, foundation one CDx, circulating tumor cells, applications.