Abstract

A CRITICAL REVIEW ON DIFFERENT METHODS OF PREPARATION OF SOLID LIPID NANOPARTICLES AND ITS CHARACTERIZATION

Baskar B.*, Dr. Selvaraju K., Karthikaa T., Sridevi M., Dr. Padma Preetha J., Nithish K.

Abstract

Solid lipid Nanoparticles (SLN) have emerged as a replacement drug delivery system with several applications within the field of pharmaceuticals, cosmetics, research, clinical drugs and different allied sciences. This review gives an overview about the potential advantages and the disadvantages of solid lipid nanoparticles, and the different methods involved in the preparation. SLN comprises the solid and lipid materials which were incorporated and by producing them as a Nanoparticle it is widely used in many of the disease conditions nowadays. The review comprises an overview on drug incorporation models, method of preparation, secondary production steps, characterization, and application. Different production strategies that area unit appropriate for big scale production and applications of solid macromolecule nanoparticles area unit delineated. There is a large analytical techniques for characterization of solid macromolecule nanoparticles like Scanning electron microscopy, differential scanning calorimetry are highlighted. If fittingly investigated, solid macromolecule nanoparticles might open new vistas in medical aid of advanced diseases.

Keywords: Solid lipid Nanoparticles; Drug release; Toxicity aspects; Preparation; Applications.