Abstract

TOXICITY STUDY OF KUSHTHAVACHADI CHOORN INHALATION IN ALBINO MICE

Vd. Swati Vinayak Gaikwad* and Dr. Sujata D. Kadam

Abstract

Background: Prolonged labor due to uterine dystocia is one of the important reasons for pregnancy complications. Kushthavachadi choorn inhalation has been advised in the charak samhita for enhancement of uterine contractions in uterine force insufficiency.[1] Very little research is being carried out during pregnancy and labour with a fear to harm the foetus and threat of legal liability. The inhalation of this choorn is advised during labor for enhancing uterine contraction. All the drugs in kushthavachadi choorn are used orally since ages. Fetal growth and maturity is ensured at full term. To rule out the inhalation toxicity of kushthavachadi choorn, animal study for inhalation toxicity of kushthavachadi choorn was carried out in pregnant Albino mice. Method-This was a controlled study where one group of pregnant Albino mice was exposed to the drug kushthavachadi choorn in a chamber with the help of nebulizer. These mice were keenly observed before and after exposed to the drug. Result: There were no sign of discomfort or behavioral changes during exposure to fumes of kushthavachadi choorn, as well as for next 24 hours after exposure to kushthavachadi choorn. All the mice in trial group delivered 24 hours earlier to that of the control group. They delivered within 24 hours of exposure to Kushthavachadi choorn inhalation, indicates that this inhalation has stimulated the uterus, that has lead to the delivery of these mice. Conclusion: Animal study reveals there is no inhalation toxicity of Kushthavachadi choorn in Albino mice. Kushthavachadi choorn inhalation has stimulated the uterus. It has uterine contractile activity.

Keywords: Dystocia, kushthavachadi choorn, inhalation toxicity, parturation.