Abstract

FORMULATION AND EVALUATION OF AZITHROMYCIN SOLID DISPERSION USING POLOXAMER

T. Raja Sekharan*, Appikatla Deepthi, R. Kannan, Ganapathi Thappatla and Kasirao Ragulakollu

Abstract

Solid dispersion technique is used to improve the dissolution/ bioavailability of poorly water soluble drug. When the drug is incorporated with water soluble carriers the dissolution /bioavailability can be increased. Azithromycin is a poorly water soluble drug. In this study azithromycin solubility is increased with the help of poloxamer 188 and 407. The solid dispersion was prepared by solvent evaporation method. The drug and the carrier compatibility study were determined with the help of IR spectroscopy. The prepared formulations were evaluated for percentage yield, drug content and dissolution studies. With the help of dissolution datas the release kinetics was determined. The formulations showed satisfied drug release.

Keywords: Azithromycin, poloxamer-188 and 407, solid dispersion, solvent evaporation method.