Abstract

COMPARATIVE EFFICACY, SAFETY AND COMPLIANCE OF LONG-TERM ANTIBIOTIC TREATMENT WITH SHORT-TERM ANTIBIOTIC TREATMENT IN CHILDREN WITH ACUTE LOWER RESPIRATORY TRACT INFECTION

Isharath Ebrahim*, Divya Sebastian, Nikitha Abraham, Niyas Ahammed A., Jereena E. and Jyothi Vijayan

Abstract

To compare the efficacy, safety and compliance of short-term course of Azithromycin with a long-term course of Amoxicillin-clavulanate in the treatment of children with Acute Lower Respiratory Tract Infection (ALRTI). A prospective observational study was conducted in 172 outpatients diagnosed with ALRTI. Azithromycin was administered as a single dose for 3 days and Amoxicillin-clavulanate was given TID for 7-10 days. The diagnosis of LRTI was based on the presence of clinical signs and symptoms associated with LRTI along with Microbiological evidence chest consolidation. The percentage of patients clinically cured plus improved was 95.3% for Amoxicillinclavulanate whereas 93% for Azithromycin. This difference was not statistically significant (p

Keywords: Amoxiciilin-clavulanate, Azithromycin, compliance, LRTI and PAMAQ.