Abstract

DESIGN AND EVALUATION OF CURCUMIN SMART BIOGELS LOADED WITH TAPOICA SAGO BIOPOLYMER FOR NOVEL DERMAL DELIVERY

Siddharth Singh* and N. V. Satheesh Madhav

Abstract

The natural therapeutics products has been served for the treatment of various diseases from a very ancient time has been reported into the medical world. Curcumin has been documented with multiple biomedical applications like anti-tumor, anti-inflammatory, antiseptic, anti-aging, wound healing, etc. Wound healing is a multiple side process carried out by four overlapping subsequent phases such as, hemostasis, inflammation proliferation and remodeling. Platelets aggregation occurred due to hemostasis which results into clot formation. The Tapoica sago polymer extracted and characterized for presence of various functional group. The main aim of research was to formulate biogels for dermal delivery systems by using a biopolymer isolated from Tapioca Sago for exploring the curcumin potential in the wound healing process. Five biogels were prepared [NG1 to NG5] and loaded curcumin with other co-processing agents. All formulations were prepared between the ratio Curcumin: bio-polymer[1:1, 1:2, 1:3, 1:4, 1:5] and subjected to evaluation parameters like pH, conductivity, spreadability, viscosity, Primarily screening techniques for determining Particle size and in-vitro drug release studies and statistical analysis performed. The NG2 formulation was found to be best formulation having 6.6pH, 5517 cps viscosity, 7.5g.cm/s spreadibility, 0.1ms conductivity, and 78.76% drug release, T50% 4.28 h and T80% 24.38 h with R2 value 0.9420 and higuchi matrix was best fit model followed the supercase II transport release mechanism. The conclusion was drawn that bio-polymer can be used as a stabilizer cum as retardant and also used in various other types of drug delivery systems and curcumin loaded biogel formulations can be used for wound healing by using dermal route.

Keywords: Curcumin; Tapoica sago; Biopolymer; Biogels; Wound healing; Dermal delivery; Drug vehicle.