Abstract

ANTI-ARTHRITIC AND ANTI-INFLAMMATORY ACTIVITY OF SHIVA GUGGULU W.S.R. TO AAMAVATA

Dr. Swapnali S. Patil* and Dr. Raman Belge

Abstract

Introduction - Rheumatoid arthritis (RA) is a chronic, inflammatory condition of unknown etiology, affecting approximately 1% of the general population. It is a progressive, disabling, chronic multisystem disease that is characterized by pain, swelling and stiffness of the synovial joints. In the 9th century A.D., Indian physician, Madhava wrote a full description of Aamavata. Aim & Objective- To study Anti-Arthritic and Anti-Inflammatory Activity of Shiva Guggulu w.s.r. to Aamavata. Methodology - Shiva Guggulu (SG) has a significant role in RA, it is refered from Rasayoga Sagar(2ndvolume).It contains Gandhaka, Triphala, Erandataila, Guggulu, Rasna, Vidanga, Maricha, Danti, Shunthi and Devadaru. The current research paper will discuss about the pharmacodynamic and pharmacokinetic actions of Shiva guggulu. A review of various research articles have proved the anti-arthritic and anti-inflammatory activity of these ingredients. Gandhak-(Sulphur) (Katu, Tikta, Kashay, Ushna, Madhur, Katu) possess Antiinflammatory & Anti-bacterial activity. Eranda taila-(Ricinus communis) (Madhur, Kashay, Ushna, Madhur) possess Antinociceptive activity in writing test, formalin induced paw licking and tail immersion method in mice. Guggulu-(Commiphera mukul) (Tikta, Katu, Ushna, Katu) possess Anti-inflammatory & Anti-arthritic activity. Haritaki-(Terminalia chebula) (Pancharasa (Kashay+), Ushna, Madhur) possess Anti-inflammatory, Immunomodulatory activity and vasodilatory effect. Bibhitak-(Terminalia bellerica) (Kashay, Ushna, Madhur) possess Anti-inflammatory & Analgesic activity. Amalaki- (Embelica officinalis) (Pancharasa (Amla+), Shita, Madhur) Anti-oxidant, Anti-lipidemic & vasodilator effect. Rasna- (Vanda roxburghii) (Tikta, Ushna, Katu) possess Anti-inflammatory & Analgesic activity. Vidanga-(Embelia ribes) (Katu, Kashay, Ushna, Katu) possess Anti-inflammatory & Analgesic activity. Maricha-(Piper nigrum) (Katu, Ushna, Katu) possess Anti-inflammatory & Analgesic activity. Danti-(Baliosperma monatano) (Katu, Ushna, Katu) possess Anti-inflammatory & Analgesic activity. Shunthi-(ZIngiber officinalis) (Katu, Ushna, Madhur) possess Anti-inflammatory & Anti-oxidant activity. Devadaru-(Cidrus deodara) (Tikta, Ushna, Katu) possess Anti-oxidant & Anti-lipidemic activity. Conclusion- Shiva Guggulu is a Herbomineral formulation. These herbominerals are experimentally proven for their Anti-inflammatory, Anti-arthritic and Analgesic activity. Hence Shiva Guggulu can be useful in the patients of Rheumatoid arthritis.

Keywords: Aamvata, Pain, Rheumatoid arthritis, Rigveda, Shiva Guggulu.