Abstract

FORMULAION AND EVALUATION OF ORALLY DISINTEGRATING TABLETS OF RIZATRIPTAN BENZOATE REVIEW

Sandeep Aher* Dr. Salunkhe K. S Dr. Chaudhari S. R

Abstract

Formulation research is oriented towards safety , efficacy &and quick onset of action of existing drug molecule through novel concepts of drug delivery . Orally disintegrating tablet of Rizatriptan benzoate were prepared by direct compression method to provide faster relief from pain to migraine sufferers . Due to problem of swallowing ability with age , The paediatric and geriatric patient complian of difficulty to take conventional solid dosage forms . The ODT’s are solid dosage forms that dissolves and disintegrates rapidly in the oral cavity. This results in solution or suspension without the need of water. Mian objective of this work to formulate and evaluate Rizatriptan Benzoate ODT’s using different concentration of super disintegrating agents like croscarmellose , Sodium starch glycolate (SSG) , Crospovidone . Tablets were prepared by direct compression method and evaluate for hardness, thickness, friability, disintegration time, and percentage drug release . the results indicated that formulation prepared with Crospovidone was found to be optimised which provides maximum drug release (100%) and minimum disintegrating time.

Keywords: Orally disintegrating tablets, Superdisintegrant , Rizatriptan Benzoate , Direct compression , Croscarmellose , Sodium starch glycolate , Crospovidone .