Abstract

FORMULATION AND EVALUATION OF MATRIX SUSTAIN RELEASED TABLETS OF ATENOLOL

S. Shivam*, Dr. P. Arun, P. Shailendra, D. Neelesh and S. Aditya

Abstract

Matrix tablets of Atenolol were prepared utilizing natural polymer chitosan. The tablets represented sustained drug release which is required for the drugs like Atenolol with low bioavailability and low half life. The tablets can sustain the drug release which can overcome such problems. Moreover the tablets contain chitosan which also is a permeability enhancer and hence could be utilized to increase the permeability of the drugs like Atenolol with very low permeability. The tablets possess high potential for being developed as sustained release dosage forms for drugs with low permeability, bioavailability and lower half life. Oral route is one of the most popular routes of drug delivery due to its ease of administration, patient compliance, least sterility constraints and flexible design of dosage form Over 90% of the formulations manufactured today are ingested orally. This shows that this class of formulation in the most popular worldwide and the major attention of the researcher is toward this direction. With advanced in technology and increase in awareness, toward modification in standard tablets is done to achieve better acceptability as well as bioavailability because of which newer and more efficient tablet dosage forms are being developed.

Keywords: Atenolol, HPMC 15cps, Na- CMC.