Abstract

IN SILICO IDENTIFICATION OF POTENTIAL DRUG TARGET AND ANALYSIS OF EFFECTIVE SINGLE NUCLEOTIDE POLYMORPHISMS FOR OVARIAN AND BREAST CARCINOMAS

Souvagyalaxmi Sahoo*, Sonalin Rath and Debasrita Das

Abstract

Breast cancer is one of the most common and important diseases affecting women. Treatment of advanced breast cancer is often futile and disfiguring, making early detection a high priority in medical management of the disease. Ovarian cancer, although less frequent than breast cancer, is often rapidly fatal and is the fourth most common cause of cancer mortality in women. The differences at the molecular level between breast and ovarian cancers were studied. However the advances in genetics and genomics science and technology have the potential to revolutionize health care, so the number of reports investigating disease susceptibility based on the carriage of low -penetrance, high frequency SNPs has increased in recent years as SNPs are the most important and basic form of variation in the genome, and they are responsible for genetic effects that produce susceptibility to diseases. The collection of associated Single Nucleotide Polymorphisms of the target genes became efficaciously carried out with the involvement of SIFT, PolyPhen2, PROVEAN and SNAP2, which results 8 nsSNPs with rsIDs i.e, rs17861094, rs41279188, rs4987133, rs34260157, rs28399430, rs56240201, rs9282671, and rs28933368 of selected 3 drug target genes i.e.,CYP1A1, CYP1B1, ERBB2 against Breast and Ovarian carcinomas. The finding of this current study not solely revealed the foremost necessary target genes, however conjointly it provides the associated single nucleotide polymorphisms can take one step nearer or forward to unravel the complicated structure of common deadly diseases especially Breast and Ovarian Cancer.

Keywords: Breast and Ovarian Carcinomas, SNPs, Genes.