Abstract

FORMULATION AND IN-VITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF TELMISARTAN USING VARIOUS HYDROPHILIC POLYMERS

Hamid Khan*

Abstract

The formulation and in-vitro evaluation of matrix tablets containing telmisartan as sustained release using various hydrophilic polymers such as different grades of HPMC and PVP by wet granulation method. The tablets were subjected to in-vitro drug release study in hydrochloric acid buffer of pH 1.2 (0.1N) with 1% w/v SLS using USP paddle apparatus. The drug released at various time intervals were determined by validated UPLC-PDA method. The prepared tablets showed better sustained release effect when compared with marketed tablets. The drug release mechanism from hydrophilic polymers was established. The formulated tablets provided sustained release of telmisartan over a period of 24 h.

Keywords: Telmisartan, HPMC, PVP, Hydrophilic polymer, Sustained release.