Abstract

INHIBITION OF PLEOMORPHISM IN PATHOGENIC FUNGI- NEW GENERATION ANTI-FUNGALS

Aruna V.*, Soundharya R., Amruthavalli G.V. and Gayathri R.

Abstract

The development of new generation anti-fungal drugs must focus on newer targets than the conventional nucleic acid biosynthesis inhibition or cell wall biosynthesis inhibition etc. several fungal pathogens have developed synanthropophization and anthropophization and become obligate parasite of man. Targeting such super specialized parasite requires newer approaches and techniques. We in the present paper made an attempt to inhibit the parasitic conversion of fungal skin pathogens. Most of the skin fungi convert to parasitic stage only then they can colonize and infect the human skin and scalp. Therefore, blocking the parasitic conversion also can serve as a potential target to prevent fungal infections and the fungi being pathogenic. Such method also may avoid unnecessary anti-fungal burden and drug resistance. The present paper deals with the scope and promise of such new generation anti-fungals from herbs.

Keywords: Drug resistance, anti-fungal, fungal cream.