Abstract

BROMOCRIPTIN AND PERGOLIDE TREATMENT ON PARKINSON DISEASE

*Onny Ziasti Fricillia and Yufita Ratnasari Wilianto

Abstract

Parkinson disease (PD) was first described by dr. James Parkinson in 1817 as “shaking palsy” (DeMaagd and Philip, 2015). PD is a disease with a degenerative process involving dopaminergic neurons in substantia nigra (the area of basal ganglia which produces and stores dopamine neurotransmitter). This area is important in extrapyramidal system which controls posture and coordination of body movements (Wagner, 2008). Parkinson's disease is the second most common neurodegenerative disorder after Alzheimer's disease (Rizek, Kumar and Jog, 2016; Elbaz, 2016).

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