Abstract

META-ANALYSIS: MYOPIA IN PATIENTS WITH OPEN-ANGLE GLAUCOMA

Jumanah Jameel Homsi*, Omar Khalid Alsaawi, Dai Samran Almutairi, Najlaa Samran Almutairi, Malak Khalid Alkuwaykibi, Abdulaziz Hussam Abed, Sara Nasser Albqami, Fahad Saud Alanazi, Mohammad Hamid Alfallaj, Faisal Mahmoud Turkistani, Abdulrahman Ghazi Alqurashi

Abstract

Background & Purpose: Myopia is a risk factor for open-angle glaucoma that could complicate both the diagnosis and treatment of glaucomatous disorder. presently, there may be a growing prevalence of myopia in lots of regions of the world. The Aim of this work is to provide cumulative data about the effect of myopia as a risk factor for Open-Angle Glaucoma (OAG). Methods: A systematic search was performed of PubMed, Cochrane library Ovid, Scopus & Google scholar to identify Ophthalmology RCTs, clinical trials, and comparative studies, which studied the outcome of OAG group versus Control group of patients. A meta-analysis was done using fixed and random-effect methods. The primary outcome was the rate any myopia. Secondary outcomes were high and low myopia rates. Results: A total of 5 studies were identified involving 20578 eyes with 5627 eyes in OAG group, and 14951 eyes in Control group. Regarding primary outcome measures, the fixed-effects model of the meta-analysis study showed highly significant increase in all myopia in OAG group compared to Control group (p < 0.01). Regarding secondary outcome measures, the fixed-effects model of the meta-analysis study showed significant increase in high myopia in OAG group compared to Control group (p = 0.025). The fixed-effects model of the meta-analysis study showed highly significant increase in low myopia in OAG group compared to Control group (p < 0.01). Conclusion: To conclude, myopia become associated with an increased occurrence of all forms of open-angle glaucoma and OHTN (ocular hypertension).

Keywords: Myopia, Open-Angle Glaucoma.