Abstract

ORODISPERSIBLE TABLETS: A NOVEL FAST DISSOLVING DRUG DELIVERY OF ANTI-PSORIATIC DRUGS

Ravindranath Bhanudas Saudagar, Darshana Pravinchandra Panhale* and Sheetal Bhaskar Gondkar

Abstract

Psoriasis and Psoriatic arthritis are chronic skin disease of autoimmune system that is identified as patches of abnormal skin, affecting 2-5% of the world’s population. Psoriasis is an incurable lifetime disease which can be controlled and relieved through medication. Treatment of psoriasis includes topical therapy, systemic therapy and phototherapy. Solid dosage forms are popular because of low cost, ease of administration, accurate dosage self-medication, pain avoidance, and the most importantly the patient compliance. However, drawback of the conventional oral treatment such as tablets is Dysphagia, Common complaints about the difficulty in swallowing tablets are size, surface, and taste of tablets. Geriatric and pediatric patients and traveling patients, who may not have ready access to water, are most in need of easy swallowing dosage forms. To fulfill these medical needs, a novel oral dosage form known as Orodispersible tablets which disperses/dissolves/disintegrates rapidly in saliva, usually within a matter of seconds, without the need of water. Drug dissolution and absorption, as well as onset of clinical effect and drug bioavailability, can be significantly greater than those as compared with conventional treatment of psoriasis.

Keywords: Psoriasis, Treatment of Psoriasis, Apremilast, Orodispersible Tablets, Advantages, Technologies for Preparing Orodispersible Tablets.