EVALUATION OF ANALGESIC ACTIVITY OF NAAGA SANGU PARPAM IN SWISS ALBINO MICE BY EDDY’S HOT PLATE METHOD
Kingsley J.*, Murugavel R., Anbarasan B., Uthrapathi S. and Sivakkumar S.
Abstract
To evaluate analgesic activity of herbal formulation Naaga Sangu
Parpam and compare it with pentazocine by using Eddy’s hot plate in
mice. The animals were divided into 4 groups of six animals in each
group. Group I received ghee (vehicle control). Group II animals
received 10 mg/kg/i.p of pentazocine. Group III and group IV received
Naaga Sangu parpam 13mg/kgb.wt and 26mg/kg b.wt respectively. In
Eddy‟s hot plate method, Naaga Sangu Parpam showed analgesic
activity 180 minutes after drug administration with mean pain
tolerance time of 4.08±0.38 seconds while pentazocine showed
analgesic activity at 180 minutes with pain tolerance time 5.5±0.6. Naaga Sangu Parpam at
the dose of 26 mg/kg exhibits significant (p
Keywords: Naaga Sangu Parpam, Eddy’s hot plate, Pentazocine.
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