Abstract

NEW SPECTROPHOTOMETRIC METHOD FOR DETERMINATION TRIFLUOPERAZINE HYDROCHLORIDE IN PHARMACEUTICAL PREPARATIONS BY USING OXIDATIVE COUPLING REACTION

Mohauman Mohammad Al-Rufaie*, Kasim Hassan kathem

Abstract

A simple, rapid and sensitive spectrophotometric method for the determination of microgram amounts of Trifluoperazine Hydrochloride drug in aqueous solution is described. The method is based on the Oxidative coupling reaction between Trifluoperazine hydrochloride and para brome aniline in the presence of sodium periodate and Hydrochloride acid to form an intense colored product with maximum absorption at 556 nm. Beer’s law is obeyed over the concentration range of( 0.4 – 6.4) ppm with molar absorptivity of 1.1296 ×105l.mol-1.cm-1 and Sandell`s sensitivity of 0.003 μg.cm-2 . The method does not resort to temperature control or to solvent extraction. The optimum conditions for all colour development are described and the proposed method has been successfully applied for the determination of Trifluoperazine hydrochloride in bulk drug and pharmaceutical Preparations(Stellamide, Stellasil and Iralzin drugs). The common excipientsand additives did not interfere in this method

Keywords: Trifluoperazine Hydrochloride, Oxidative coupling Spectrophotometric Determination.