A NOVEL VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF IVERCITIN AND ALBENDAZOLE IN BULK AND TABLET COMBINED DOSAGE FORMS
Muggu. Muralikrishna*, M. Lakshmi Surekha, R. Padma and Ch. Ajay
Abstract
The present work deals with the development of a precise, accurate,
simple, specific, reliable and less time consuming RP-HPLC method
for the estimation of Ivercimectin and Albendazole tablets. The
chromatographic separation was achieved on a Inertsil C18 ODS(4.6 x
water (50:50) v/v at a flow rate of 1.0 ml/min, and the detection was
carried out by using PDA detector at 290 nm. Ambient column
temperature has maintained. The total run time was 10mins.The
retention time of Ivercimectin and Albendazole were found to be 2.9
min. and 3.5 min. respectively. The performance of the method was
validated according to the present ICH guidelines.
Keywords: RP-HPLC, Ivercimectin and Albendazole, Inertsil C18 ODS.
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