Abstract

PREPARATION AND EVALUATION OF SUSTAINED RELEASE TABLET BY USING NATURAL GUM AS RELEASE RETRADANT

P. Sapna*, Dr. P. Arun, P. Shailendra, P. Bhavesh and D. Neelesh

Abstract

Despite many advances in the development of oral hypoglycaemic agents, an ideal drug for treating Type 2 diabetes is still a distant. The age-old molecules such as sulfonylureas and biguanides are still considered drugs of choice because of their well-studied mode of action, safety, better tolerability and ideal pharmacodynamic effects. Until we find an ideal drug for Type 2 diabetes, there is much scope and interest for pharmaceutical companies to modify the pharmacokinetics of older molecules in order to better suit larger sections of patients his compilation is an attempt to describe the advances in drug delivery of oralhypoglycaemic agents, particularly the extended and sustained release formulations of glipizide and metformin, both of which have great promise in treatment of Type 2 diabetes mellitus. The drug selected for the present investigation was metformin hydrochloride, a biguanide, is an orally active antidiabetic agent. It is more used in the treatment of non-insulin dependent diabetes mellitus (NIDDM).

Keywords: Shimadzu FTIR 8700, UV Vis Doublebeam Spectrophotometer, Metformin Hcl, guar gum, sustained release tablet by using natural gum as release retardan, oral hypoglycaemic agents.