Abstract

IN VITRO THROMBOLYTIC AND ANTI-ARTHRITIC ACTIVITY OF HOMALOMENA AROMATICA LEAVES

Shakawat Hossain, Arfa Khanum, Mifta Ahmed Jyoti, Israt Jahan, Md. Zahid Hasan, Seratul Mustakim, Shabnur Mahmud Shilpi, Md. Abdul Hamid* and Ajoy Roy

Abstract

The present study was designed to investigate the thrombolytic & antiarthritic activity of methanolic extract of leaves of Homalomena aromatica. Thrombolytic effect of the fraction was investigated in the clot lysis experiment. The extract exerted 58.67% & 29.47% lysis of the blood clot in thrombolytic activity test while 67.823% & 10.687% lyses were obtained for the positive control (streptokinase) and negative control respectively. And the Homalomena aromatica extract possessed great thrombolytic activity which compounds are liable for the present pharmacological actions and to know their mechanism of action, extensive pharmacological and phytochemical experiments are essential. In vitro arthritic activity, inhibition proteinase actions were evaluated to assess the anti-arthritic effect of the selected plant extracts were assessed by using a hypotonic solution. In highest concentration of Homalomena aromatica, shows significant anti-arthritic activity (53.16%, 43.04%, 35.44%, 30.38%, and 21.52%) compared with Diclofenac-Na. Further in-depth studies on this plant can result in an eco-friendly cost effective anti-arthritic herbal drug with anti-inflammatory potential contributing towards the better healthcare of human society.

Keywords: Homalomena aromatica, Thrombolytic, Anti-arthritic, Protein denaturation.