Abstract

META-ANALYSIS OF PSORIASIS AND CARDIOVASCULAR RISK FACTORS

Wasan Rwaibeh Al Qurashi*, Joud Abdulshakur Basfar, Zainab Mansour Abualsaud, Raja Mohsin S. Alibrahim, Dr. Abdullah Nasser Alomair, Dr. Nawaf Fawzan Alfawzan, Nujud Muteb Alshammari, Ghadah Mohammed Alnajjar, Seham Saad ALQahtani, Zahra Shaker Al Kalaif

Abstract

Background & Purpose: More recently, research have shown that psoriasis is a systemic inflammatory disease which may be related to numerous comorbidities. particularly, psoriasis is associated with an accelerated threat of developing intense vascular events such as myocardial infarction and stroke. in addition, the prevalence rates of cardiovascular risk factors are accelerated, including high blood pressure, diabetes mellitus, dyslipidemia, obesity, and metabolic syndrome. The Aim of this work is to provide cumulative data about the effect of cardiovascular risk factors on psoriasis patients. Methods: A systematic search was performed of PubMed, Cochrane library Ovid, Scopus & Google scholar to identify Dermatology RCTs, clinical trials, and comparative studies, which studied the outcome of Psoriasis group versus Control group of patients. A meta-analysis was done using fixed and random-effect methods. The primary outcome was the rate of Ischemic Heart Disease (IHD). Secondary outcomes were atherosclerosis and hypertension (HTN). Results: A total of 5 studies were identified involving 1255118 patients, with 32171 patients in Psoriasis group, and 1222947 patients in Control group. Regarding primary outcome measures, the fixed-effects model of the metaanalysis study showed highly significant increase in IHD in Psoriasis group compared to Control group (p< 0.01). Regarding secondary outcome measures, the random-effects model of the meta-analysis study showed highly significant increase in atherosclerosis in Psoriasis group compared to Control group (p < 0.01). The random-effects model of the meta-analysis study showed highly significant increase in HTN in Psoriasis group compared to Control group (p = 0.001). Conclusion: To conclude, there is strong association between the prevalence of cardiovascular risk factors and major cardiovascular events and psoriatic patients.

Keywords: Psoriasis, Ischemic Heart Disease, atherosclerosis, hypertension.