Abstract

AN EVALUATION OF ANTI-DIABETIC EFFECTS OF EDIBLE OILS ON ALLOXAN INDUCED RATS WITH SAFETY PROFILE ANALYSIS

Nahin Al Alam*, Momsad Sakib, Tahani Jashim, Lia Rose Merry D. Cruze, Nadia Afrin and Md. Kamrul Hasan

Abstract

Edible oils are a great source for nutrient and culinary purposes. Plant derived edible oil could be considered as a source of remedy against Diabetes Mellitus. Because being plant derivatives; these oils are sources of numerous compounds which can be used as a therapeutic agent to ameliorate diabetes mellitus. Our aim is to identify antidiabetic activity of edible oils, so that these oils can be used in meditative purpose. In our study alloxan was induced in rats by an by intraperitoneal injection at a dose of 150mg/Kg body weight and oils were fed to the rats at a dose of 2ml/kg. We measured blood glucose level, and safety profile by measuring SGOT, SGPT and creatinine on diabetic and non-diabetic rats before and after administration of the extract. After measuring the blood glucose level, it was found that oils are capable of providing hypoglycemic efficacy in diabetic rats significantly. Safety profile was investigated by checking SGOT, SGPT and creatinine levels. It was seen that though all oil can improve the diabetic condition, still there are some differences in their strength. Furthermore, in healthy individual rats, no oil can significantly alter normal physiological state. It can, therefore, be inferred that certain edible oils could be used as a good alternative therapy to treat diabetes.

Keywords: Edible Oil, Diabetes Mellitus, Alloxan, Hypoglycemic Effect.