Abstract

SYNTHESIS AND CHARACTERISATION OF SOME NOVEL MANNICH BASES OF THIAZOLIDINONES DERIVED FROM PYRAZOLINES

Prerana Pujari, Ramesh V MeenaChandran*, David Paul, A R Bhat,K Krishnakumar

Abstract

The main approach of medicinal chemistry is to synthesize compounds that show promising activity as therapeutic agents with lower toxicity. Thiazolidinone and Pyrazoline derivatives may show different activities such as analgesic, anti-inflammatory, antitubercular activitiesetc. Mannich base derivatives of Thiazolidinones from Schiff bases have been synthesized by reacting them with previously prepared Pyrazolines from Chalocnes, with the yield ranging from 56% to 71%. The identification and characterization of the synthesized compounds were carried out by melting point, TLC and FT-IR to ascertain that all prepared compounds were of different chemical nature than the respective parent compound.

Keywords: Thiazolidinone, Pyrazoline, Mannich Base, Schiff Bases, Chalcones.