Abstract

COMPARATIVE STUDY OF GLYCEMIC CONTROL AND DIABETIC COMPLICATIONS IN T2DM PATIENTS WITH AND WITHOUT THYROID DYSFUNCTION IN A TERTIARY CARE TEACHING HOSPITAL

Dr. Merin Titus*, Anjumol S. Varghese, Athul N. Vikram, Bindhya Mariyam Xavier, Donna Maria Thomas

Abstract

The coexistence of T2DM with thyroid dysfunction is a known clinical observation. Patients with DM may be at an increased risk of thyroid disease and further thyroid abnormalities can have an adverse effect on metabolic control, glycemic control, dyslipidaemia and cardiovascular risk. Alteration in thyroid function could negatively impact diabetes and its control. Aim of the study is to compare glycemic control and diabetic complications in T2DM patients with and without thyroid dysfunction, to assess thyroid status and to compare it with glycemic control and diabetic complications. A 6 months case control study was conducted among 100 patients which included 50 T2DM patients (Control) and 50 T2DM patients with thyroid dysfunction (Case) who attended SSIMS&RC, Davangere. The information compiled from patient data collection form was assessed for FBS, HbA1c, BMI, Thyroid profile, Lipid profile, Creatinine, Urea as well as the prescribing pattern. Sub clinical hypothyroidism was the most commonly found thyroid status in T2DM patients which is predominantly seen in females. The average FBS and HbA1c value was higher in case, specifically individuals with clinical hyperthyroidism. Among study population, majority of diabetic complications were found in case specifically sub clinical hypothyroidism with HTN being the most common followed by IHD. Recognition and treatment of thyroid dysfunction in diabetic patients will benefit glycemic control, attenuate cardiovascular risk and improve general well being.

Keywords: T2DM; Thyroid dysfunction; Glycemic control; Diabetic complication.