Abstract

REVIEW ARTICLE: SOLUBILITY ENHANCEMENT BY SOLID DISPERSION

Dipali Bhandari*, Dr. Ashok Bhosale, Trusha Shangrapawar, Amit Lunkad and Narhari Patil

Abstract

Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system. Enhancement of solubility, dissolution rate and bioavailability of the drug is a very challenging task in drug development, nearly 40% of the new chemical entities currently being discovered are poorly water soluble drugs. The solubility behavior of the drugs remains one of the most challenging aspects in formulation development. This results in important products not reaching the market or not achieving their full potential. Solid dispersion is one of the techniques adopted for the formulation of such drugs and various methods are used for the preparation of solid dispersion. Solid dispersion is generally prepared with a drug which is having poor aqueous solubility and hydrophilic carrier. This article reviews techniques of solubility enhancement, various methods and concept of solid dispersion, classification of solid dispersion, advantage and disadvantage, characterization, and application.

Keywords: Solid dispersion, Solubility enhancement.