Abstract

ACUTE AND CHRONIC TOXICOLOGICAL STUDY ON THIRILOGA CHENDOORAM - A HERBO METALLIC SIDDHA FORMULATION IN WISTAR RAT

S. Rajesh*, C. Eswaran, S. Merish and M. Prakash

Abstract

Introduction: Thiriloga chendooram is a Siddha Herbo Metallic preparation predominately used for treatment of Iron deficiency Anaemia, Oedema and Jaundice. Administration of Thiriloga Chendooram (TC) without proper purification in human body may lead to severe complications. Hence the main aim of the work is to study the toxic effects of short term and long term administration of Thiriloga Chendooram (TC). Methods: The acute oral toxicity study was performed in Wistar albino rats of 6 groups and each group consisting of 5 rats at 1ml of suspension containing doses ranging from 40-640mg of Thiriloga Chendooram. Animals were observed at the end of 24 hours. The Chronic toxicity study into 3 groups each group consisting of 5 rats. The preparation was done in such a way so as 1 ml of suspension contained 40mg and 80mg of the drug and was administered for 90 days. Results: In acute toxicity study did not produce any mortality even up to 640 mg/body weight of the animal. In chronic toxicity study As per findings of long term administration of Thiriloga Chendooram in the dose level of 40mg, 80mg/100gm body weight of the animals produced had not any remarkable tissue changes to liver, kidney except mild interstitial odema and haemorrhages in heart at the dose level of 40mg & 80mg administered animals. Conclusion: Thiriloga Chendooram was found to be Safe upto 640mg/body weight of the animals. There was no mortality observed and ensures the safety nature of the drug.

Keywords: Siddha medicine, anaemia, chendooram, acute toxicity, chronic toxicity.