Abstract

AN IN VIVO ASSESSMENT OF ANTIHYPERLIPIDEMIC EFFECT OF NIGELLA SATIVA ON HIGH FAT INDUCED HYPERLIPIDEMIC RAT MODEL

Md. Mehedi Hasan Khandoker*, Furhatun-Noor, Lia Rose Merry D. Cruze, Md. Kamrul Hasan, Amira Mostafa, Nadia Afrin and Zahirul Islam

Abstract

Seeds of Nigella sativa is one of the well-known seed that is used for treatment of hyperlipidemia traditionally. In our study, high fat induced hyperlipidemia in rats were treated with Nigella sativa extract with a dose of 500 mg/kg in one group of rats and atorvastatin with a dose of 50 mg/kg in another group. We measured total cholesterol, Triglyceride, HDL and LDL level of rat. It was found that the hypolipidemic efficacy of Nigella sativa was comparable to that of atorvastatin (p> 0.05). It was seen that both atorvastatin and seed of Nigella sativa improved the pathological condition induced by high fat. Furthermore, in healthy individual rats, both atorvastatin and seed extract of Nigella sativa did not significantly alter normal physiological state. It can, therefore, be inferred that seed oil of Nigella sativa could be utilized as a good alternative therapy to treat hyperlipidemia.

Keywords: Nigella sativa, atorvastatin, hyperlipidemia, total cholesterol, HDL, LDL, triglyceride.